Reflectance confocal microscopy (RCM) is a new non-surgical alternative to skin biopsy. The laser-assisted imaging device can deliver cellular level detailed black and white images that allow diagnosis of melanomas with 95% sensitivity and 86% specificity. A dermatoscopic image is correlated with the confocal image for a more powerful analysis. The RCM image is completely different from a light microscopic image, and the technology is creating a new branch of dermatopathology.
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